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    Adenoviral Vectors for Gene Therapy

    Adenoviral Vectors for Gene Therapy by Curiel, David T.; Parker, Alan L.;

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      • Publisher's listprice EUR 231.00
      • The price is estimated because at the time of ordering we do not know what conversion rates will apply to HUF / product currency when the book arrives. In case HUF is weaker, the price increases slightly, in case HUF is stronger, the price goes lower slightly.

        97 990 Ft (93 324 Ft + 5% VAT)
      • Discount 10% (cc. 9 799 Ft off)
      • Discounted price 88 191 Ft (83 992 Ft + 5% VAT)

    97 990 Ft

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    Product details:

    • Edition number 3
    • Publisher Academic Press
    • Date of Publication 25 April 2025

    • ISBN 9780323898218
    • Binding Hardback
    • No. of pages906 pages
    • Size 235x191 mm
    • Weight 450 g
    • Language English
    • 700

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    Long description:

    Adenoviral Vectors for Gene Therapy, Third Edition, provides detailed, comprehensive coverage of gene delivery vehicles based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, as platforms for gene therapy and gene editing, as well as for oncology approaches, making them class leading agents in the gene-advanced therapies arena.

    The fully updated and expanded third edition covers the basic biology of adenoviruses and highlights the potential use of adenoviral vectors for the treatment of disease, including their construction, propagation, and purification, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models. The book also considers the regulatory issues surrounding human clinical gene therapy trials. New chapters include adenoviral vaccines for veterinary applications, adenoviruses for gene editing, nonhuman primate adenoviruses, COVID-19 vaccines, vaccine applications, and oncolytic adenoviruses for antitumor immunization. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.


    • Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors
    • Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement
    • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
    • Discusses the utility of adenoviral vectors in animal disease models
    • Considers Food and Drug Administration regulations for human clinical trials

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    Table of Contents:

    1. Structural Biology of Adenovirus
    2. Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms
    3. Adenovirus Replication
    4. Adenoviral Vector Construction I: Mammalian Systems
    5. Adenoviral Vector Construction II: Bacterial Systems
    6. Adenoviral Vector Packing Cell Lines
    7. Purification of Adenovirus
    8. Innate Immune Response to Adenovirus
    9. Antibodies to Adenovirus
    10. Methods to Mitigate Immune Response
    11. Xenogenic Adenoviral Vectors as Vaccines
    12. Adenoviral Vector Targeting
    13. Helper-Dependent Adenovirus
    14. Hybrid Adenoviral Vectors
    15. Canine Adenovirus
    16. Oncolytic Adenovirus
    17. Imaging Analysis
    18. Adenoviral Vaccines - Cancer
    19. Adenoviral Vaccines - Infectious Disease
    20. Adenoviral Vaccines - COVID 19
    21. Adenoviral Vectored Veterinary Vaccines
    22. Utility of Adenoviral Vectors in Animal Models - CV Disease
    23. Utility of Adenoviral Vectors in Animal Models - Pulmonary Disease
    24. Utility of Adenoviral Vectors in Animal Models - Genetic Disease
    25. Adenoviral Vectors for Gene Editing
    26. Manufacturing and Upscaling
    27. Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective

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    Adenoviral Vectors for Gene Therapy

    Adenoviral Vectors for Gene Therapy

    Curiel, David T.; Parker, Alan L.; (ed.)

    97 990 HUF

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