?-Carbolines
A Privileged Scaffold for Modern Drug Discovery
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Product details:
- Edition number 1
- Publisher CRC Press
- Date of Publication 29 November 2024
- ISBN 9781138482388
- Binding Hardback
- No. of pages282 pages
- Size 234x156 mm
- Weight 453 g
- Language English
- Illustrations 242 Illustrations, black & white; 242 Line drawings, black & white; 5 Tables, black & white 776
Categories
Short description:
?-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse ?-carboline scaffold and their biological evaluation.
MoreLong description:
?-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse ?-carboline scaffold and their biological evaluation.
?-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse ?-carboline scaffold and their biological evaluation.
Features:
- Focuses on the different application and therapies of ?-carbolines.
- Provides a summary of methods for the synthesis of various natural products engineered with the diverse ?-carbolines.
- Discusses methods of biological evaluation of ?-carbolines.
- Explores different chemical transformations occurring with synthesis using ?-carbolines.
- Covers both heterocyclic synthesis and multicomponent synthesis related to ?-carboline.
This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of ?-carbolines.
MoreTable of Contents:
Chapter 1 ?-Carbolines as anti-cancer agents: Synthesis and biological study
Chapter 2 ?-Carbolines as anti-bacterial agents: Synthesis and biological study
Chapter 3 ?-Carbolines as antifungal agents: Synthesis and biological study
Chapter 4 ?-Carbolines as Kinase Inhibitor: Synthesis and biological study
Chapter 5 Sulfur-containing ?-carbolines: Synthesis and biological study
Chapter 6 Anti-malarial Activity and ?-Carboline Derivative: A Synthetic Approach
Chapter 7 ?-carbolines as antioxidant agents: Synthesis and biological study
Chapter 8 ?-Carbolines as anti-inflammatory and anti-depressant agents: Synthesis and biological study
Chapter 9 ?-Carbolines as Anti-HIV agents: Synthesis and biological study
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