Short description:

Lung transplantation (LTx) is a life-saving treatment for people with very severe end-stage lung diseases. It educates healthcare professionals involved in the care of LTx patients by explaining the general post-transplant journey, addressing typical post-transplant complications, and providing examples of real-life cases.

Long description:

Lung transplantation (LTx) is a life-saving treatment for people with severe end-stage lung disease. This concise, well-illustrated practical handbook provides a comprehensive overview of pre-, peri-, and post-transplant care addressing the complexity of lung transplantation, general follow-up, and common post-transplant complications. Simple, to-the-point short topics will answer potential questions by LTx trainees, fellows, and consultants; educating healthcare professionals involved in the care of LTx patients explaining the post-transplant journey along with examples of real-life cases.

Key Features

• Presents answers to common clinical questions during the post-transplant journey of a lung transplant recipient


• Shares practical/pragmatic approaches to diagnostic and management issues seen in the lung transplant population for clinicians from both within and external to transplant centres internationally, to gain practical experience


• Summarises the clinical aspects of LTx, with easy-to-navigate short text blocks, bullet points, and illustrations

Table of Contents:

1. Lung transplantation. 1.1 Lung transplantation: where are we today? 1.2  Ethical considerations regarding lung transplantation. 2. Pre-transplant. 2.1  Indications for lung transplantation. 2.2  How to select a good recipient? 2.3  A patient on the waiting list: how to manage and when to transplant. 2.4  How are organs allocated? 2.5  How to select a good donor? 3. Peri-transplant. 3.1 Type of lung transplantation. 3.2 Type of procedure. 3.3  ECMO, cardiopulmonary bypass and off-pump. 3.4  What is ischaemia time? 3.5  Should we use ex vivo lung perfusion? 3.6   To induce or not? 4. Post-transplant medication and follow-up. 4.1 Maintenance immunosuppression. 4.2 Prophylaxis. 4.3 What to expect after lung transplantation?. 4.4  General follow-up post-transplant. 4.5  Surgery in lung transplant patients. 4.6  Pregnancy and lung transplantation. 4.7 Medication interactions. 5. General post-operative complications and primary graft dysfunction . 5.1Pleural complications. 5.2  Ischaemic airway complications and fistulas. 5.3  Other post-operative complications. 5.4   Primary graft dysfunction (PGD). 6. Post-transplant complications: rejection. 6.1 Introduction acute and chronic rejection. 6.2  Hyperacute rejection: does it still exist?.6.3  Acute cellular rejection (ACR). 6.4  Donor specific antibodies (DSA): what and how to interpret?6.5  Antibody-mediated rejection (AMR). 6.6  Chronic rejection: chronic lung allograft dysfunction (CLAD). 6.7  Bronchiolitis obliterans syndrome (BOS). 6.8  Restrictive allograft syndrome (RAS). 6.9  Biomarkers and future therapies. 7. Other common post-transplant complications. 7.1 Infections. 7.2 Malignancies. 7.3 Kidney dysfunction. 7.4Metabolic complications and cardiovascular disease. 7.5  Reflux and other gastrointestinal issues: why it matters. 7.6  PRES: posterior reversible encephalopathy syndrome. 8. Clinical cases. 1.3Clinical case: early post-operative evolution. 1.4 Clinical case: ACR, infection and CLAD . 1.5Clinical case: CMV infection. 1.6  Clinical case: PTLD