Overview of Genetic Factors & Environmental Triggers in the Pathogenesis of Tourette's Syndrome
Series: Neuroscience Research Progress;
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Product details:
- Edition number 1
- Publisher Nova Science Publishers, Inc (US)
- Date of Publication 22 September 2010
- ISBN 9781616687489
- Binding Paperback
- No. of pages59 pages
- Size 140x215 mm
- Weight 116 g
- Language English 0
Categories
Long description:
Tourette's syndrome (TS) is an inheritable, childhood-onset neuropsychiatric disorder characterised by the presence of motor and phonic tics. Despite decades of extensive studies, the exact disease aetiology remains poorly understood. It is believed that susceptibility to TS is determined by the interactions of multiple genetic loci with unknown environmental factors. As a result, a great deal of research has been focused on identifying TS susceptibility genes. Thus far, at least 12 susceptibility loci have been suggested by genome-wide screenings, but none of them has been replicated probably due to genetic heterogeneity. Candidate gene approach has also suggested evidence for several genes relevant to neuronal signalling such as dopamine receptor and serotonin receptor. This book discusses the current state of genetic studies in TS susceptibility.
MoreTable of Contents:
Introduction; Clinical Characteristics of TS & its Impact on Quality of Life (QOL); Genetic Factors for Tourette's Syndrome; Update of Linkage/Association Studies; Progress for the Analysis of Chromosomal Abnormalities; Environmental Triggers in Tourette's Syndrome; Food Chain & TS; Psychosocial Stress & TS; Changes for Life Style & TS; Challenges for Future Genetic Study of TS; Association versus Linkage: The Right Choice for Future Study; Candidate Genes versus Genome-Wide Approach; Summary & Remarks; Index.
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