Long description:

Reconstructive Transplantation and Regenerative Surgery: The New Frontier is the third volume in the Regenerative and Transplant Medicine Series. The past decade has witnessed the convergence of reconstructive surgery with tissue engineering and regenerative medicine leading to the inception of the new field of regenerative surgery. The driving force for such multidisciplinary integration is to overcome the current limitations of vascularized organ or tissue transplantation. In this volume the topics span graft immunomodulation (cell therapies, immunobiologics), neuroregeneration (neurobiologics) and graft targeted therapeutic (implanted local immunomodulatory/suppressive therapeutics, gene editing, immunocloaking) diagnostic strategies (non-invasive molecular/multimodality imaging of rejection, nanotheranostics), ischemia mitigation/graft preservation, multimodality imaging strategies and biosensors in graft surveillance. Reconstructive Transplantation and Regenerative Surgery: The New Frontier is written by the world’s experts in the field, it is perfect for surgeons, clinicians, trainees, scientists, and academics working to advance the field.

• Third volume in the Regenerative and Transplant Medicine Series, focusing on the vascularized organ / tissue transplantation
• Includes an overview of the field, including developments of transplantation methods and techniques
• Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals

Table of Contents:

Part I - History of Reconstructive Transplantation
1. Emergence of Reconstructive Transplantation and the Evolution of Regenerative Surgery

Part II - Program, Patient and Policy Update
2. Current Status of VCA - A World Update
3. Complications and Mortality in VCA
4. The UNOS - OPTN Mandate for VCA - Emerging Policy and Impact

Part III - Decisions and Dilemmas in Reconstructive Transplantation
5. Lower Limb Transplantation - World Experience
6. Complex Combined VCA - Are We Ready?
7. Face Transplantation versus Conventional Reconstruction

Part IV - The Cutting Edge of Reconstructive Transplantation
8. Surgical Planning in Face Transplants - From Simulation to Execution
9. The Sensitized VCA Recipient - Regimens and Risks
10. Whole Eye Transplantation

Part V - Unique Considerations and Emerging Indications in Reconstructive Transplantation
11. Thyroid Transplantation - Indications and Challenges
12. Tracheal Transplantation - Lessons Learned and Current Progress
13. Penile Transplantation - The Ethics of VCA for Gender Affirmation REGENERATIVE SURGERY

Part VI - Graft Targeted Therapies
14. Local Graft Cellular Therapies for Immunomodulation in VCA
15. Biomaterials for Immune Regulation
16. Microneedles for Targeted Immunosuppressive Drug Delivery

Part VII - Cellular and Regenerative Therapies in Reconstructive Transplantation
17. Mixed Chimerism in Reconstructive Transplantation
18. Novel Senolytic Therapies - Translational Implications in VCA
19. Exosomal Therapies - Potential and Promise

Part VIII - Graft and Patient Monitoring in Reconstructive Transplantation
20. Nanoimaging and Nanotheranostics in Reconstructive Transplantation
21. Biomarker Surrogates for Graft Monitoring
22. Biosensors for Drug Monitoring

Part IX - Composite Tissue Graft Manipulation and Engineering
23. Composite Graft Engineering: Concepts and Challenges
24. Composite Graft Decellularization and Recellularization
25. Whole Graft Gene Editing Part X - Tissue Engineering of VCA Components
26. Bioengineered Scaffolds for VCA
27. Engineered Nervous Tissue Constructs for VCA
28. Thymic Engineering for VCA