Smith and Williams' Introduction to the Principles of Drug Design and Action - Smith, H. John; Williams, Hywel; - Prospero Internet Bookshop
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Smith and Williams' Introduction to the Principles of Drug Design and Action

 
Edition number: 4
Publisher: CRC Press
Date of Publication:
 
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Short description:

As knowledge of biological systems and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. Smith and Williams? Introduction to the Principles of Drug Design and Action, Fourth Edition provides the basic principles of rational

Long description:
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams? Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion.

See what?s new in the Fourth Edition:

Fully updates and expands the contents

Coverage of agonists and antagonists of neuro-transmitters

Information on the design of stable peptide-like drugs

The human genome and its impact on drug discovery and development

Advances in therapy and pharmacokinetics

Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

?This book consists of 17 chapters on a variety of topics related to drug design and action. ? This book is intended as a possible text for undergraduate chemistry students interested in medicinal chemistry, or for graduate students as a means to learn the basics of medicinal chemistry. ? classical approaches are described for drug design with the inclusion of the more recent context of the human genome project ? In summary, some medicinal chemists in academia or the pharmaceutical industry may find this book instructive for certain classes of biomolecules or classical approaches to drug design. It should probably be included in most comprehensive library collections of medicinal chemistry texts and monographs.?
? Bruce L. Currie, Department of Pharmaceutical Sciences, Loma Linda University, California, in Journal of Medicinal Chemistry, , Vol. 50, No. 1, 2007
?The fourth edition of this book includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. ? real-world examples that illustrate the principles of drug design ? New features of this edition include: coverage of agonists and antagonists of neurotransmitters; the design of stable peptide-like drugs; the human genome and its impact on drug discovery and development; advances in therapy and pharmacokinetics.?
? In Anticancer Research, Vol. 26, 2006
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Table of Contents:
Processes of Drug Handling by the Body. The Design of Drug Delivery Systems. Fundamental Pharmacokinetics. Intermolecular Forces and Molecular Modeling. Drug Chirality and its Pharmacological Consequences. Quantitative Structure?Activity Relationships (QSAR) in Drug Design. Prodrugs. From Program Sanction to Clinical Trials: A Partial View of the Quest for Arimidex, A Potent, Selective Inhibitor of Aromatase. Design of Enzyme Inhibitors as Drugs. Peptide Drug Design. Combinatorial Chemistry: A Tool for Drug Discovery. Recombinant DNA Technology: Monoclonal Antibodies. The Human Genome and its Impact on Drug Discovery and Therapy. The Chemotherapy of Cancer. Neurotransmitters, Agonists, and Antagonists. Design of Antibacterial, Antifungal, and Antiviral Agents. Pharmaceutical Applications of Bioinorganic Chemistry. Index.