The Lung: Development, Aging and the Environment, Third Edition provides an understanding of the multifaceted nature of lung development, aging and the environment influences of these processes. As an essential resource to respiratory, pulmonary and thoracic scientists and physicians, this book provides an interface between the "normal" and "disease" cluster of chapters, allowing for a natural complement. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the "normal" pediatric lung.

New research, including cell-based strategies for infant lung function, epigenetics and prenatal environmental exposure (including wildfires) on lung development and function are some of the important additions to this edition of this reference work.

Describes the normal processes of lung development, growth and aging
Considers the effects of environmental contaminants in the air, water, soil and diet on lung development, growth and health
Describes genetic factors involved in susceptibility to lung disease
Covers respiratory health risk in children
Includes a number of new hot topics surrounding epigenetics, climate influences on growth, development and aging, biomarkers, sex differences, wildfires, coronavirus, E-cigarette vaping, and microbiome

Table of Contents:

Part I: Critical Events in Normal Development and Aging 1. Lung Progenitor Cell Specification and Morphogenesis 2. Alveolar Development 3. Development of the Innervation of the Lower Airways: Structure and Function 4. Pulmonary Vascular Development 5. Developmental Physiology of the Pulmonary Circulation 6. Physical, Endocrine, and Growth Factors in Lung Development 7. The Development and FUnction of the Pulmonary Surfactant System in Health, Prematurity, and Genetic Disease 8. Ontogeny of the Pulmonary Immune System 9. Macrophages and the Lung 10. Adaptation to Mechanical Signals in the Lung: Recruitment of Reserves, Remodeling, and Regrowth 11. Pulmonary Transition at Birth 12. Normal Aging of the Lung Part II: Environmental and Disease Influences on Lung Development and Aging 13. Epigenetics and the Developmental Origins of Lung Disease 14. Pulmonary Consequences of Preterm Birth 15. Preterm Birth and the Developing Lung: Programming Effects on Lung Structure and Function 16. The Effects of Neonatal Hyperoxia on Lung Development 17. Restricted Growth During Early Development: Effects on Lung Structure and Lung Function 18. Cell-Based Strategies for the Treatment of Injury to the Developing Lung 19. Effects of Environmental Tobacco Smoke during Early Life Stages 20. Nicotine Exposure during Early Development: Effects on the Lung 21. Implications of Early Life Exposures to Electronic Nicotine Delivery System (ENDS) Aerosols 22. In Utero Exposure to Allergens and Development of the Allergic Phenotype in the Neonate 23. Effect of Environment on the Developing and Adult Pulmonary Surfactant System and in the Aging Lung 24. Environmental Determinants of Lung Aging 25. The Role of Epigenetics in Lung Diseases and Environmental Exposures 26. The Dynamic Microbiotal Changes in the Human: Impact on the Developing Lung 27. Viral Respiratory Pathogens and Lung Injury in Pregnancy, with Focus on Epidemiology and Pathophysiology of ARDS amidst the COVID-19 Pandemic 28. The Lung Exposome: Accelerating Precision Respiratory Health