| ISBN13: | 9780443186530 |
| ISBN10: | 0443186537 |
| Binding: | Hardback |
| No. of pages: | 608 pages |
| Size: | 276x216 mm |
| Weight: | 450 g |
| Language: | English |
| 766 |
TRP Channels as Therapeutic Targets
EUR 175.00
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TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. Chapters are completely updated, withe new topics on TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. This is a great reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline will also find this book helpful for biologic principles of action.
- Presents the perspectives of several life science research specialties on the topic
- Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice
- Represents an updated and complete reference
1. A brief introduction to trp channel biology
2. The crystal structure of trp channels: implications for drug discovery
3. TRP channel dysfunction in hereditary diseases ("TRP channelopathies")
4. Altered trp channel expression in acquired disease
5. TRP gene polymorphism and disease risk
6. Targeting trpv1 channels for pain relief
7. Trpa1 antagonists for pain relief
8. TRP channels and migraine
9. Emerging pain targets: trpm and trpc channels
10. Trp channels in bladder disorders
11. TRP channels in respiratory diseases
12. TRP channels: emerging targets in covid and its complications
13. TRP channels and cerebrovascular diseases
14. Targeting TRP channels for relief from itch
15. TRP channels in dermatological disorders
16. TRP channels in hypertension
17. TRP channels in diabetes, obesity, and metabolic syndrome
18. TRP channels cardiovascular disease
19. TRP channels and digestive disease
20. TRP channels and cancer
21. TRP channels for anxiety relief and for improving mental health
22. TRP channels and neurodegenerative disorders
23. Mucolipidosis
24. TRP channels and renal disease
25. TRP channels and arthritis
26. TRP channels and thermoregulation: therapeutic opportunities