| ISBN13: | 9781032515335 |
| ISBN10: | 1032515333 |
| Binding: | Hardback |
| No. of pages: | 232 pages |
| Size: | 254x178 mm |
| Language: | English |
| Illustrations: | 4 Illustrations, black & white; 31 Illustrations, color; 24 Halftones, color; 4 Line drawings, black & white; 7 Line drawings, color; 6 Tables, black & white |
| 700 |
TRP-Mediated Signaling
GBP 145.00
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The field of Transient Receptor Potential (TRP) channels has gained momentum in recent years partially because of the growing appreciation of the diverse and important physiological and pathophysiological functions of this diverse family of cation channels.
The field of transient receptor potential (TRP) channels has gained momentum in recent years not only because of the 2021 Nobel Prize in Physiology or Medicine awarded to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch, but also because of the growing appreciation of the diverse and important physiological and pathophysiological functions of this diverse family of cation channels. In the past decade, there have been important discoveries in the TRP field: resolution of the 3-D structures of major subfamilies using single-particle cryogenic electron microscopy and X-ray crystallography, identification and development of selective agonists and antagonists for most TRP subfamily members, discovery of new human diseases associated with TRP gene mutations, as well as improved understanding of TRP channel function and regulation in various systems. These new discoveries are addressed in TRP-Mediated Signaling, a volume in the Methods in Signal Transduction book series.
Key Features
? Summarizes recent advances in the study of TRP channels
? Written by a team of leading international researchers
? Reviews physiological and pathophysiological functions of TRP channels
? Identifies diseases associated with TRP gene mutations
? Examines the evolution of temperature-sensing TRP channels
Chapter 1. Recent advances in the structural pharmacology of TRPC channels. Chapter 2. Characterizing the structures and regulation of TRPV channels using Cryo-EM. Chapter 3. Role of the TRPM2 channel as a ROS sensing and signaling mechanism in ischemia-reperfusion brain damage. Chapter 4. Investigating TRP channel function with tools for high-precision manipulation of gating mechanism by light. Chapter 5. Pathophysiological role of TRPC1 in cell function. Chapter 6. TRPM4 and TRPM5 Channels as Chemical-to-Electrical Signal Converter. Chapter 7. Physiological and pathological functions of TRPML1. Chapter 8. TRP Channels in Cardiac Diseases. Chapter 9. Vascular Function Mediators: TRP Channels in Endothelial and Smooth Muscle Cells. Chapter 10. Study of TRP Channels in Stroke. Chapter 11. Evolution of thermosensitive TRP channels as a source of sensory diversification and environmental adaptation.
