Hosszú leírás:

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Tartalomjegyzék:

1. Proteomics technologies for the global identification and quantification of proteins

Ian A. Brewis and P. Brennan

2. Targeted metabolomics and mass spectrometry

E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths

3. Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling

Tatyana Karabencheva and Christo Christov

4. Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling

Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees

5. Positive and Negative Modulation of Nicotinic Receptors

Hugo R. Arias

6. Sonochemically Born Proteinaceous Micro- and Nanocapsules

Elena D. Vassileva and Neli S. Koseva