| ISBN13: | 9780443222221 |
| ISBN10: | 0443222223 |
| Kötéstípus: | Puhakötés |
| Terjedelem: | 400 oldal |
| Méret: | 235x191 mm |
| Nyelv: | angol |
| 700 |
Bacterial Enzymes as Targets for Drug Discovery
EUR 170.00
Kattintson ide a feliratkozáshoz
Bacterial Enzymes as Targets for Drug Discovery: Meeting the Challenges of Antibiotic Resistance addresses the gap between medical microbiology, structural biology, and genomic science in the development of new antibacterial drug development. This book consolidates detailed profiling of bacterial target enzyme families for the drug discovery process and methodologies for use and validation of the potential drug targets. The content covers the foundations of antibiotic drug discovery process and focuses on bacterial enzymes as drug targets, building a bridge between microbiology, structural biology, and genomic science. This is the ideal reference for antibiotic drug discovery researchers in the pharma industry and academia. Biochemists, microbiologists, and medicinal chemists will also benefit from this books’ content.
- ??Provides strategies and approaches to drug design with an aim to overcome antibiotic resistance
- Includes the most common roadblocks on the research process and learnings from failed projects
- Provides potential new drug targets identified by genome mining
1. Antibacterial drug discovery: A Silent Pandemic
2. Current scenario and future prospective of drug discovery and development against bacterial enzymes
3. Clinical diagnostics of bacterial infections and their resistance to Antibiotics - Current State and Novel Enabling Technologies Implementation Perspectives
4. An Odyssey into Phylogenetic Functional Conservation of Novel Antibacterial Targets in Human Pathogens
5. Validation of drug targets using molecular methodologies and enzymatic activity assays for validation of inhibitory potential
6. Computational tools to identify potential drug targets in bacteria
7. Antimicrobial drug resistance and bypassing strategies
Part II Bacterial enzyme as drug targets
8. Designing Tomorrow's Antibiotics: Cutting-Edge Strategies and Technologies
9. Inhibiting the replication by targeting topoisomerases
10. Role of beta lactamases in antibiotic drug discovery
11. Selective vs broad spectrum inhibition of novel outer membrane targets in Gram negatives
12. Ribosomal binding antibacterial agents
13. RNA polymerase: A key target for Novel Antimicrobial Therapeutic Strategies
14. Colistin resistance and strategies against superbug, where we are?
15. Deoxythymidine pathway enzymes as an antibacterial target
16. Arresting the peptidoglycan synthesis to kill the bacteria
17. Clp protease complex as a therapeutic target for tuberculosis
18. PlaF: a bacterial Lands cycle phospholipase A mediating membrane phospholipid degradation and virulence adaptation
19. Bacterial TIR domain-containing proteins as drug targets
20. Drug Repurposing: Tackling the antibiotic resistance with existing therapeutics