Hosszú leírás:

Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.

The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.

The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.

• Covers basic science and clinical disorders
• Includes homeostatic aspects of sleep regulation
• Discusses effects of sleep and sleep deprivation on cognition and behavior
• Provides quantitative models of sleep-wake dynamics
• Reviews epidemiology, clinical picture, and treatment of disorders
• Identifies pharmacological and nonpharmacological treatments of insomnia
• Explores sleep disorders accompanying Parkinson’s, Alzheimer’s and other disorders

Tartalomjegyzék:

Section I. Basic Science
1. Effects of light on biological functions and human sleep
2. The crucial intersection of light and circadian rhythms for alertness and cognition
3. Impact of sleep deprivation on dynamic functional connectivity states
4. Sleep and circadian rhythms modelling: from hypothalamic regulatory networks to cortical dynamics and behavior
Section II. Clinical
5. Advanced sleep phase syndrome: role of genetics and aging
6. Irregular sleep wake rhythm disorder: from the pathophysiologic perspective to the treatment
7. Shift work sleep disorder
8. Human sleep and immunity: The role of circadian patterns
9. Circadian pattern in restless legs syndrome
10. Circadian rhythm disorders in the blind
11. Sleep and circadian rhythms after traumatic brain injury
12. Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: the link with the neurodegeneration
13. Circadian aspects in non-pharmacological and pharmacological treatment of insomnia
14. Chronobiological treatments for mood disorders
15. Sleep and circadian dysfunction in Parkinson disease: new perspective and opportunities for treatment
16. Sleep-wake modulation and pathogenesis of Alzheimer disease: Suggestions for postponement and treatment