Rövid leírás:

This handbook discusses applications of stem cells and their secretome in regenerative medicine, covering their biology, applications, and therapeutic potential in various medical contexts, like diabetes, cancer, and neurological disorders. It is useful for researchers and professionals in regenerative medicine and stem cell biology.

Hosszú leírás:

This handbook comprehensively explores various facets of stem cells and their secretome in the field of regenerative medicine, covering topics such as the biology, characteristics, and applications of mesenchymal and non-mesenchymal stem cells in diverse medical contexts. It delves into their potential for treatment of radiation injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery. Furthermore, it investigates the potential of neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using non-genetically modified natural killer cells. The book also uncovers the possibilities of botanical leads for stem cell therapy, explores the role of stem cells in promoting healthy aging, and sheds light on their complex interplay with cancer, particularly in gliomas and gynecologic cancers. Additionally, it reviews the use of stem cell-derived insoluble factors, focusing on extracellular vesicles as therapeutic agents in dentistry, cardiovascular diseases, and neurodegenerative disorders. The chapters discuss the potential of engineering mesenchymal stem cells secretome for bone regeneration and treating intracerebral hemorrhage. Towards the end, the book elucidates cell-free scaffolding for tissue engineering, adult stem cells' disease tropism, and the evolving strategies in regenerative medicine. It is intended for researchers, professionals, and academicians in the fields of regenerative medicine, stem cell biology, and medical biotechnology.

Key Features:

• Addresses the biology, characteristics, and applications of both mesenchymal and non-mesenchymal stem cells in diverse medical contexts.


• Presents applications of stem cells for the treatment of various medical conditions, including radiation injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery.


• Covers neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using non-genetically modified natural killer cells.


• Explores the potential of botanical compounds for stem cell therapy, bridging traditional medicine with modern approaches.


• Discusses therapeutic potential of the stem cell-derived secretome in dentistry, cardiovascular diseases, and neurodegenerative disorders.

Tartalomjegyzék:

Chapter 1. Mesenchymal Stromal Cell: Basic characteristics and Interaction with the Immune System. Chapter 2. Significant Progress in Stem Cell Treatment for Alzheimer?s Disease: A Critical Review. Chapter 3. Regenerative Medicine in Ophthalmology. Chapter 4. Cell Therapy for Diabetes. Chapter 5. Revisiting Preclinical and Clinical Trials of Mesenchymal Stem Cells in Heart Disease to Define a Dose-Response. Chapter 6. Stemming Pain Sensations with Stem Cells. Chapter 7. Osteoarthritis treatment between bio-stimulation and cell therapy. Chapter 8. Cellular Architects of Healing: Mesenchymal Stem Cell-Based Strategies for Fibrosis. Chapter 9. Stem cells and mineralized plasmatic matrix therapy in oral surgery. Chapter 10. Role of stem cell-based therapy in neurodegenerative, ocular, and cardiovascular disease. Chapter 11. Stem Cells Regenerative Therapy in Cardiac Disease: Lessons from Embryonic Development, Current Evidence for Clinical Application and Potential Future Directions. Chapter 12. Challenges And Opportunities in the Study of Bone Marrow-Derived Mesenchymal Stromal Cells: From Where We Stand to Where We Go. Chapter 13. Mesenchymal stem cell-mediated therapy in regenerative medicine. Chapter 14. Routes of Administration of Mesenchymal Stem Cell Therapy in Cardiac Therapy. Chapter 15. Neuronal Stem Cells and Regenerative Medicine: Harnessing the Potential for Neural Repair. Chapter 16. Biomaterial Nanofiber Scaffolds for Neural Regeneration. Chapter 17. Cell-free and Cell-based Therapy in Treating Spinal Cord Injuries. Chapter 18. 20-Year Life Prolongation Achieved through Muscle Regeneration by Implanting 50-Billion Allogeneic Myoblasts into Duchenne Muscular Dystrophy (DMD) Boys. Chapter 19. Reversing Insulin Resistance by Novel Cell-based and Cell-free Therapy Approaches with Skeletal Myoblasts. Chapter 20. Current progress and challenges of non-genetically modified natural killer (NK) cell-based immunotherapy. Chapter 21. Identification of Potential Botanical Drug Leads for Stem Cell Therapy: Cues from Sri Lankan Traditional Medicine. Chapter 22. Cell-based Therapy for Cancer in Regenerative Medicine. Chapter 23. Lung regeneration against lung diseases: a near future reality? Chapter 24. The pivotal role of glioma stem cells in promoting glioma radio-chemoresistance, progression, and recurrence is a topic of significant interest and potential breakthroughs in neurosurgery, oncology, and molecular biology. Chapter 25. Significance of Targeting Cancer Stem Cells in Gynaecologic Cancer. Chapter 26. Role of Stem Cells in diabetes, liver disease, and cancer treatment. Chapter 27. Pluripotent Stem Cells: A Hope to Move Forward for Cardiovascular Applications.