
A termék adatai:
ISBN13: | 9781914487422 |
ISBN10: | 1914487427 |
Kötéstípus: | Keménykötés |
Terjedelem: | 320 oldal |
Méret: | 234x153x27 mm |
Nyelv: | angol |
700 |
Témakör:
Tangled Up
The History and Science of Alzheimer's Disease
Kiadó: Canbury Press
Megjelenés dátuma: 2025. április 24.
Kötetek száma: Hardback
Normál ár:
Kiadói listaár:
GBP 25.00
GBP 25.00
Az Ön ára:
10 755 (10 243 Ft + 5% áfa )
Kedvezmény(ek): 15% (kb. 1 898 Ft)
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Rövid leírás:
The only guide for the public to the science and history of Alzheimer’s disease. This book can help you if you fear that you have Alzheimer’s disease or if a friend or family member has Alzheimer’s disease.
Hosszú leírás:
The only comprehensive guide to the history and science of Alzheimer’s disease
With vivid examples, dementia expert Michael Hornberger takes you on a whistle-stop tour of every aspect of Alzheimer's disease, from its origins to modern diagnosis and treatment.
Professor Hornberger shows how you can protect yourself and your family from developing the disease. His book explains:
Alzheimer’s disease accounts for around 70% of all people with dementia and its incidence is growing.
Prof Hornberger, a neuroscientist who has researched Alzheimer’s for decades, delves into this most common form of dementia by looking at the very first patient, Auguste Deter, who was diagnosed with ‘Alzheimer’s’. Mrs Deter was interviewed by a pioneering German doctor, Alois Alzheimer. She could remember her wedding but not her husband's name or where they lived.
Generally, old memories thrive in most people with Alzheimer's disease, while newer ones are harder to remember. But, as this guide explains, some lesser-known Alzheimer's variants, such as Posterior Cortical Atrophy, do not start with memory loss.
Prof Hornberger explains the role that inherited genes play in transmitting Alzheimer's, including the important difference between risk genes and familial Alzheimer’s disease genes &&&8211; which make developing the disease a near certainty.
Finally, the book looks at new ‘biomarkers’ and blood tests to detect, diagnose and monitor Alzheimer’s, and which new treatments are emerging.
Prof Hornberger warns that popularly touted techniques to prevent Alzheimer's may not be worth your time or money. Instead, he sets out the steps you can take to protect yourself from this debilitating degenerative disease.
Reviews
‘A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease and how best to prevent it.’ &&&8211; John O’Brien, Professor of Old Age Psychiatry, University of Cambridge
‘This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.’ &&&8211; Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine
‘It expertly balances deep scientific insights with engaging storytelling... As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.’ &&&8211; Karen Duff, Centre Director, UK Dementia Research Institute, University College London
About the author
Michael Hornberger is Professor of Applied Dementia Research at the University of East Anglia in the UK. He regularly meets patients with Alzheimer’s disease as part of his research aimed at improving diagnosis, disease tracking and symptom management.
Buy the book and carry on reading
'A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease, and how best to prevent it.' &&&8211; John O'Brien, Professor of Old Age Psychiatry, University of Cambridge
'This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.' &&&8211; Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine
'An enlightening exploration of complex concepts, approached with humour and warmth, and made accessible to all. The book expertly balances deep scientific insights with engaging storytelling, providing readers with a detailed understanding of Alzheimer’s disease from its historical beginnings, to our current understanding of its effects on brain biology and memory. As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.' &&&8211; Karen Duff, Centre Director, UK Dementia Research Institute at University College London
With vivid examples, dementia expert Michael Hornberger takes you on a whistle-stop tour of every aspect of Alzheimer's disease, from its origins to modern diagnosis and treatment.
Professor Hornberger shows how you can protect yourself and your family from developing the disease. His book explains:
- What causes Alzheimer’s disease
- Why Alzheimer’s often affects memory first
- The role of genetics in raising and lowering risk for the disease
- The chances you will inherit Alzheimer’s from your parents
- The practical steps you can take to reduce your risk of getting dementia
Alzheimer’s disease accounts for around 70% of all people with dementia and its incidence is growing.
Prof Hornberger, a neuroscientist who has researched Alzheimer’s for decades, delves into this most common form of dementia by looking at the very first patient, Auguste Deter, who was diagnosed with ‘Alzheimer’s’. Mrs Deter was interviewed by a pioneering German doctor, Alois Alzheimer. She could remember her wedding but not her husband's name or where they lived.
Generally, old memories thrive in most people with Alzheimer's disease, while newer ones are harder to remember. But, as this guide explains, some lesser-known Alzheimer's variants, such as Posterior Cortical Atrophy, do not start with memory loss.
Prof Hornberger explains the role that inherited genes play in transmitting Alzheimer's, including the important difference between risk genes and familial Alzheimer’s disease genes &&&8211; which make developing the disease a near certainty.
Finally, the book looks at new ‘biomarkers’ and blood tests to detect, diagnose and monitor Alzheimer’s, and which new treatments are emerging.
Prof Hornberger warns that popularly touted techniques to prevent Alzheimer's may not be worth your time or money. Instead, he sets out the steps you can take to protect yourself from this debilitating degenerative disease.
Reviews
‘A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease and how best to prevent it.’ &&&8211; John O’Brien, Professor of Old Age Psychiatry, University of Cambridge
‘This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.’ &&&8211; Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine
‘It expertly balances deep scientific insights with engaging storytelling... As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.’ &&&8211; Karen Duff, Centre Director, UK Dementia Research Institute, University College London
About the author
Michael Hornberger is Professor of Applied Dementia Research at the University of East Anglia in the UK. He regularly meets patients with Alzheimer’s disease as part of his research aimed at improving diagnosis, disease tracking and symptom management.
Buy the book and carry on reading
'A fascinating journey, both historically and scientifically, from the first recorded case of Alzheimer’s disease through to modern therapies. This book is essential reading for anyone wanting to understand the real science behind what causes Alzheimer’s disease, and how best to prevent it.' &&&8211; John O'Brien, Professor of Old Age Psychiatry, University of Cambridge
'This is such a clear and interesting book, which takes away the fear from something to which we are all at risk. It is high time we knew more, and this is just the place to start.' &&&8211; Professor Tom Shakespeare, Professor of Disability Research, London School of Hygiene and Tropical Medicine
'An enlightening exploration of complex concepts, approached with humour and warmth, and made accessible to all. The book expertly balances deep scientific insights with engaging storytelling, providing readers with a detailed understanding of Alzheimer’s disease from its historical beginnings, to our current understanding of its effects on brain biology and memory. As we enter an era of hope in our battle against this devastating disease, Tangled Up is an invaluable resource for the curious reader, be they caregiver, scientist or medical professional.' &&&8211; Karen Duff, Centre Director, UK Dementia Research Institute at University College London
Tartalomjegyzék:
TABLE OF CONTENTS
Preface
Prologue
Part I &&&8211; Alois & Auguste (and a bit of Oskar)
Chapter 1 &&&8211; Dr Hoffmann’s vision
Chapter 2 &&&8211; Mrs Deter
Chapter 3 &&&8211; Alois Alzheimer
Chapter 4 &&&8211; Munich via Heidelberg
Chapter 5 &&&8211; 1906
Chapter 6 &&&8211; The T&&&252;bingen aftermath
Chapter 7 &&&8211; Fischer’s disease
Chapter 8 &&&8211; Alzheimer’s legacy
Part I &&&8211; Summary
Part II &&&8211; Memory and Space
Chapter 9 &&&8211; ‘You are not my type’
Chapter 10 &&&8211; The art of memory
Chapter 11 &&&8211; ‘Secret’ memory techniques
Chapter 12 &&&8211; ‘Attention!’”
Chapter 13 &&&8211; ‘Enter the seahorse’
Chapter 14 &&&8211; Encoding, storage, retrieval
Chapter 15 &&&8211; ‘It’s all about access’
Chapter 16 &&&8211; The imaginary Mrs A
Chapter 17 &&&8211; Spatial Disorientation
Chapter 18 &&&8211; ‘Lost in space’
Part II &&&8211; Summary
Part III &&&8211; Amyloid and Tau
Chapter 19 &&&8211; Glorious proteins
Chapter 20 &&&8211; Amyloid
Chapter 21 &&&8211; Beta-amyloid formation
Chapter 22 &&&8211; ‘Location, location, location… and timing’
Chapter 23 &&&8211; Tau
Chapter 24 &&&8211; ‘Who ordered all the phosphate?’
Chapter 25 &&&8211; Tau ‘infection’
Chapter 26 &&&8211; Amyloid versus Tau
Chapter 27 &&&8211; The ‘emergence’ of the disease
Chapter 28 &&&8211; Biomarker technology
Chapter 29 &&&8211; Amyloid treatment approaches
Decreasing beta-amyloid production
Prevention of beta-amyloid accumulation
Increase of beta-amyloid removal
Chapter 30 &&&8211; Tau treatment approaches
Decrease of overall tau
Decrease of tau phosphorylation
Decrease phosphorylated tau accumulation
Increase phosphorylated tau removal
Chapter 31 &&&8211; Why have drug trials failed so far?
Phase I
Phase II
Phase III
Part III &&&8211; Summary
Part IV &&&8211; Genetics and lifestyle
Chapter 32 &&&8211; Genetics 101
Chapter 33 &&&8211; Familial Alzheimer’s disease
APP
PSEN
MAPT
Chapter 34 &&&8211; ‘Modifiable’ risk genes
APOE
TREM2
Chapter 35 &&&8211; A word on genetic testing
Chapter 36 &&&8211; Non-modifiable lifestyle factors
Age
Education
Hearing loss
Chapter 37 &&&8211; Modifiable lifestyle factors
Diabetes, hypertension and obesity
Physical activity
Diet and nutrition
Sleep
Other modifiable lifestyle risk factors
Part IV &&&8211; Summary
Part V &&&8211; Rarer forms of Alzheimer’s disease
Chapter 38 &&&8211; Frontal variant Alzheimer’s disease
Chapter 39 &&&8211; Posterior Cortical Atrophy
Chapter 40 &&&8211; Logopenic variant primary progressive aphasia
Chapter 41 &&&8211; Corticobasal syndrome
Chapter 42 &&&8211; A final word on the rarer forms of Alzheimer’s disease
Part V &&&8211; Summary
Epilogue
Further country specific links (English language)
Index
Preface
Prologue
Part I &&&8211; Alois & Auguste (and a bit of Oskar)
Chapter 1 &&&8211; Dr Hoffmann’s vision
Chapter 2 &&&8211; Mrs Deter
Chapter 3 &&&8211; Alois Alzheimer
Chapter 4 &&&8211; Munich via Heidelberg
Chapter 5 &&&8211; 1906
Chapter 6 &&&8211; The T&&&252;bingen aftermath
Chapter 7 &&&8211; Fischer’s disease
Chapter 8 &&&8211; Alzheimer’s legacy
Part I &&&8211; Summary
Part II &&&8211; Memory and Space
Chapter 9 &&&8211; ‘You are not my type’
Chapter 10 &&&8211; The art of memory
Chapter 11 &&&8211; ‘Secret’ memory techniques
Chapter 12 &&&8211; ‘Attention!’”
Chapter 13 &&&8211; ‘Enter the seahorse’
Chapter 14 &&&8211; Encoding, storage, retrieval
Chapter 15 &&&8211; ‘It’s all about access’
Chapter 16 &&&8211; The imaginary Mrs A
Chapter 17 &&&8211; Spatial Disorientation
Chapter 18 &&&8211; ‘Lost in space’
Part II &&&8211; Summary
Part III &&&8211; Amyloid and Tau
Chapter 19 &&&8211; Glorious proteins
Chapter 20 &&&8211; Amyloid
Chapter 21 &&&8211; Beta-amyloid formation
Chapter 22 &&&8211; ‘Location, location, location… and timing’
Chapter 23 &&&8211; Tau
Chapter 24 &&&8211; ‘Who ordered all the phosphate?’
Chapter 25 &&&8211; Tau ‘infection’
Chapter 26 &&&8211; Amyloid versus Tau
Chapter 27 &&&8211; The ‘emergence’ of the disease
Chapter 28 &&&8211; Biomarker technology
Chapter 29 &&&8211; Amyloid treatment approaches
Decreasing beta-amyloid production
Prevention of beta-amyloid accumulation
Increase of beta-amyloid removal
Chapter 30 &&&8211; Tau treatment approaches
Decrease of overall tau
Decrease of tau phosphorylation
Decrease phosphorylated tau accumulation
Increase phosphorylated tau removal
Chapter 31 &&&8211; Why have drug trials failed so far?
Phase I
Phase II
Phase III
Part III &&&8211; Summary
Part IV &&&8211; Genetics and lifestyle
Chapter 32 &&&8211; Genetics 101
Chapter 33 &&&8211; Familial Alzheimer’s disease
APP
PSEN
MAPT
Chapter 34 &&&8211; ‘Modifiable’ risk genes
APOE
TREM2
Chapter 35 &&&8211; A word on genetic testing
Chapter 36 &&&8211; Non-modifiable lifestyle factors
Age
Education
Hearing loss
Chapter 37 &&&8211; Modifiable lifestyle factors
Diabetes, hypertension and obesity
Physical activity
Diet and nutrition
Sleep
Other modifiable lifestyle risk factors
Part IV &&&8211; Summary
Part V &&&8211; Rarer forms of Alzheimer’s disease
Chapter 38 &&&8211; Frontal variant Alzheimer’s disease
Chapter 39 &&&8211; Posterior Cortical Atrophy
Chapter 40 &&&8211; Logopenic variant primary progressive aphasia
Chapter 41 &&&8211; Corticobasal syndrome
Chapter 42 &&&8211; A final word on the rarer forms of Alzheimer’s disease
Part V &&&8211; Summary
Epilogue
Further country specific links (English language)
Index