A termék adatai:
ISBN13: | 9780443159640 |
ISBN10: | 0443159645 |
Kötéstípus: | Puhakötés |
Terjedelem: | 275 oldal |
Méret: | 234x190 mm |
Súly: | 450 g |
Nyelv: | angol |
700 |
Témakör:
The Physics of Protein Structure and Dynamics
When and Why Proteins Fold or Don't Fold
Kiadó: Academic Press
Megjelenés dátuma: 2024. október 17.
Normál ár:
Kiadói listaár:
EUR 148.00
EUR 148.00
Az Ön ára:
54 965 (52 348 Ft + 5% áfa )
Kedvezmény(ek): 10% (kb. 6 107 Ft)
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Hosszú leírás:
The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses.
Tartalomjegyzék:
1. Introduction 2. Intramolecular and Intermolecular Interactions 3. Protein Dynamics 4. Protein Folding and Unfolding 5. Intrinsically disordered proteins and poly-peptides 6. Misfolding and peptide/protein aggregation 7. Summary and Outlook